The immune system plays a crucial role in protecting us from diseases, but factors like stress, poor diet, and pollution can disrupt its function. Keeping the immune system optimal is key to maintaining a healthy life. One natural solution that is gaining popularity is Andrographis paniculata, also known as the King of Bitters. This herbal plant has long been used in traditional medicine across Asia to treat diseases such as respiratory infections, the flu, cough, and digestive disorders.
Andrographis and the Immune System
Our immune system is divided into two main components: innate immunity and adaptive immunity. Innate immunity acts quickly to fight infections, while adaptive immunity involves T and B cells that are more specific in recognizing and fighting pathogens. In a recent study on the effects of Andrographis paniculata on immune health, it was found that Andrographis leaf extract (SAPE) can enhance the adaptive immune response, particularly by increasing lymphocytes, T cells, and CD4+ T-helper cells. The study also showed an increase in cytokines like IFN-γ and IL-4, which play a role in modulating the balance between Th1 and Th2 responses.
This study revealed that supplementation with Andrographis paniculata (sambiloto) extract can enhance the adaptive immune response, as evidenced by an increase in total lymphocytes, T cells, CD4+ helper T cells, and cytokines such as IFN-γ and IL-4, along with a decrease in IL-2 levels—without causing any significant side effects.
Benefits and Potential Uses of Andrographis Paniculata for Immunity
– Increasing T Cells and CD4+ T-helper Cells
Supplementation with Andrographis can help increase the number of T cells and CD4+ T-helper cells, which are vital in maintaining the balance of the body’s adaptive immunity. This is important for helping the body recognize and address infections.
– Stimulating Cytokine Production
Cytokines, such as IFN-γ and IL-4, involved in the Th1 and Th2 immune responses, significantly increase after consuming Andrographis. This helps enhance the body’s ability to combat viruses and bacteria.
– Anti-Viral and Anti-Inflammatory
In addition to boosting the immune system, Andrographis also has broad anti-viral properties, including fighting flu viruses, dengue, chikungunya, and hepatitis B and C. This makes it a valuable addition for dealing with seasonal viral infections.
Andrographis paniculata holds great potential in enhancing the immune system naturally and without significant side effects. It can be an effective herbal option to support the body’s resilience. However, it is always recommended to consult with a healthcare professional before starting regular use.
Source : Rajanna, M., Bharathi, B., Shivakumar, B. R., Deepak, M., Prashanth, D., Prabakaran, D., Vijayabhaskar, T., & Arun, B. (2021). Immunomodulatory effects of Andrographis paniculata extract in healthy adults – An open-label study. Journal of Ayurveda and integrative medicine, 12(3), 529–534. https://doi.org/10.1016/j.jaim.2021.06.004
