How Red Ginger Works for Hypertension?

High blood pressure affects millions worldwide—yet one of the most promising natural supports may come from a small, fiery-red rhizome found across Asia: Red Ginger. Known for its potent bioactive profile, this herbal ingredient has gained increasing scientific attention as a natural antihypertensive agent. 


What Makes Red Ginger Special? 

Red ginger (Zingiber officinale var. rubrum) contains higher concentrations of gingerol and shogaol compared to regular ginger. These compounds give it a stronger pharmacological profile, contributing to antioxidant, anti-inflammatory, immunomodulatory, and cardiovascular benefits. 

For centuries, red ginger has been used in Asian herbal medicine to treat: 

• headaches 

• digestive disturbances 

• bacterial infections 

• fever 

• autoimmune complaints 

• even as supportive therapy in cancer 


How Red Ginger Works for Hypertension 

According to Yunas et al. (2024), red ginger affects blood pressure through multiple mechanisms: 

Gingerol & shogaol inhibit inflammatory mediators such as: 

  • cytokines 
  • chemokines 
  • leukotrienes 
  • prostaglandins 

Via suppression of: 

  • COX-1 
  • COX-2 
  • 5-lipoxygenase (5-LO) 

B. ACE (Angiotensin-Converting Enzyme) Inhibition 

Zingerone, gingerol, and shogaol help reduce ACE activity — which is essential because ACE is responsible for blood vessel constriction. 

➡ Research showed 10.80% ACE activity reduction in rats at a dose of 360 mg / 200 g body weight

C. Vasodilation & NO Regulation 

Red ginger promotes vasodilation by: 

  • enhancing nitric oxide (NO) production 
  • preventing excessive NO accumulation 
  • improving endothelial (vascular) function 

➡ Result: smoother blood flow & reduced vascular resistance. 


Why Red Ginger Is Recommended 

The combined anti-inflammatory action, ACE inhibition, and vasodilation provide a multi-pathway approach that is more holistic than relying on single-mechanism drugs. Red ginger extract is an excellent natural adjunct for hypertension management thanks to its ability to:  

  • relax and widen blood vessels 
  • reduce inflammatory load 
  • support cardiovascular function 
  • help regulate blood pressure naturally 

This makes it a strong candidate for protective use or complementary therapy.  


Source :  

Yunas, R. W., Rahmawat S. I., Saputri, F. C., Bayu A., Chianese G., Pura M. Y. 2024. Roselle and Red Ginger: A Potential Combination of Medicinal Plants for Hypertension Therapy. Pharmaceutical Sciences and Research (PSR), 11(3), 118–134. 

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