Centella Asiatica, often called Gotu Kola, is a widely celebrated plant in the cosmetic and skincare industry. It has gained immense popularity due to its potent abilities in stimulating collagen synthesis, improving skin hydration, and providing anti-aging benefits. This article delves into the scientific evidence supporting Centella Asiatica’s role in enhancing collagen levels and skin hydration.
Centella Asiatica and Collagen Synthesis
Centella Asiatica is rich in triterpenoids like asiaticoside, which have demonstrated the ability to stimulate fibroblast proliferation and activate the SMAD signaling pathway, leading to the production of type I collagen. One study revealed that the application of cream with or without Centella Asiatica extract for four weeks led to an increase in collagen levels in the skin of female rats. This finding is consistent with research by Lee and colleagues, which observed that Centella Asiatica could stimulate fibroblasts to produce more collagen, help reduce the formation of stretch marks, and lower inflammation.

The active compound asiaticoside from Centella Asiatica has also been found to improve blood circulation in the skin and prevent excessive fat accumulation in cells. Through consistent use, asiaticoside activates SMAD3 and SMAD4, facilitating collagen production by modulating the SMAD signaling pathway. This mechanism is essential for skin regeneration, resulting in healthier and more youthful skin.
Centella Asiatica and Skin Hydration

In addition to its collagen-boosting effects, Centella Asiatica also significantly enhances skin hydration. Studies have shown that the application of a cream containing Centella Asiatica extract increases skin hydration levels over a four-week period. These benefits were attributed to the active constituents—polyphenols and glycosides—found in the hydroethanolic extract of Centella Asiatica. These compounds act as antioxidants, anti-elastase, anti-aging agents, and contribute to photochemoprotective properties, which ultimately improve skin hydration and elasticity.
Centella Asiatica is a powerhouse ingredient in skincare, with proven benefits for both collagen synthesis and skin hydration. The plant’s ability to stimulate collagen production through the activation of the SMAD signaling pathway and its rich content of active compounds make it a valuable ingredient in anti-aging and skin hydration treatments. Research has shown that Centella Asiatica offers a natural and effective solution for improving skin condition, combating aging, and maintaining optimal hydration levels.

Source : Venesia, N. F., Fachrial, E., Lister, N. E. (2020). Effectiveness Test of Centella Asiatica Extract on Improvement of Collagen and Hydration in Female White Rat (Rattus Norwegicus Wistar). American Scientific Research Journal for Engineering, Technology, and Sciences (ASRJET). Volume 65, No 1, pp 98-10